Abstract: High entropy alloy is widely used in the field of active damage materials because of its excellent mechanical properties and reaction release properties.In response to the common issues of traditional energetic structural materials, such as fluoropolymer-based materials, intermetallic compounds, and amorphous materials generally having low strength, this paper summarizes and organizes the current research status on the mechanical performance advantages and impact energy release characteristics of high-entropy alloys. High-entropy alloys possess basic traits such as high strength, high hardness, high wear resistance, and excellent combinations of plasticity. Moreover, their composition and properties can be adjusted over a wide range to meet material requirements in different scenarios. At the same time, high-entropy alloys have potential advantages in terms of machinability, high strength, and impact energy release, making them promising candidates for high-strength reactive damage materials. In particular, the Ti-Zr-based systems have become a research focus due to their penetration-energy coupling effects, and existing experimental results have also confirmed the application potential of high-entropy alloys. Currently, high-entropy alloys show great application prospects in warhead casings and energetic fragments. This paper introduces the definition and characteristics of high-entropy alloys, elaborates on their impact energy release properties and characterization methods, summarizes the reactive high-entropy alloy systems studied so far, outlines the application prospects of reactive high-entropy alloys, and further explores the future development directions of high-entropy alloys in the field of reactive damage.