Abstract: To address the challenge of evaluating the internal stress of materials or structures in service environments, a method combining finite element analysis and micro-indentation testing is proposed. Taking the CoCrFeNiMn high-entropy alloy as the research object, compression, shear and micro-indentation tests were carried out under different loading speeds respectively. Based on the asymmetric initial yield function, Swift hardening and the associated flow rule, the elastoplastic constitutive model of this material was established. The constitutive model was programmed by using the stress integration algorithm and interfaced with the ABAQUS finite element software. Furthermore, by comparing the finite element simulation results and experimental results of the split Hopkinson pressure bar (SHPB) and the indentation model, the reliability of the model was verified. Based on the SHPB model, the numerical simulation of the dynamic compression experiment was carried out, and the stress fields at different dynamic deformation moments were imported into the indentation model as the initial stress (internal stress) fields for indentation simulation analysis./t/nThe results show that the initial stress field in the loading stage will significantly reduce the indentation load at the same indentation depth, and the reduction amplitude increases with the increase of stress. In addition, the existence of the initial stress field will further weaken the stress concentration during the indentation process. Through the quantitative analysis of the indentation displacement-load curves under different compression amounts, the indentation response laws of materials under different initial stress conditions were revealed. The research results provide a reference for the evaluation of the internal stress of materials or structures under service conditions.